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Anastrozole has been tested for reducing estrogens, including estradiol, in men. [13] Excess estradiol in men can cause benign prostatic hyperplasia , gynecomastia , and symptoms of hypogonadism . It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer. [14] Some athletes and body builders use anastrozole as part of their steroid cycle to reduce and prevent symptoms of excess estrogen-- gynecomastia , emotional lability and water retention. [13] Study data suggest dosages of  mg to 1 mg a day reduce serum estradiol by approximately 50% in men, which differs in postmenopausal women. [15]

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