Nandrolone what is it used for

Due to its chemical structure nandrolone is weakly exposed to aromatase (only 20% of the aromatizing activity of testosterone).  However, not estrogenic effects are its main concern:  nandrolone has a potent progestogenic activity (20% of progesterone).  While binding to progestogenic pituitary receptors nandrolone causes increased production of prolactin, which in effect is very similar to estrogen: its effect presents in reducing testosterone production, increasing fat mass and in gynecomastia. To prevent these side effects prolactin inhibitors (cabergoline) shall always be at hand when on nandrolones cycle.

Even if a drug is rated low in estrogenic activity, unwanted and often unpleasant side effects are possible.
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  A number of factors can influence how any individual person reacts to the androgenic and anabolic effects of an anabolic steroid:

There are possible estrogenic side effects of Nandrolone despite it not being a very estrogenic hormone, at least not directly. Nandrolone does aromatize slightly. Aromatization refers to the conversion of testosterone to estrogen . This takes place when the testosterone hormone interacts with the aromatase enzyme. When the conversion takes place this can cause estrogen levels to go up, which can promote gynecomastia and water retention. High blood pressure can also become an issue if water retention becomes severe. Along with the low level of aromatase activity Nandrolone is also a progestin and has a strong binding affinity for the progesterone receptor. This may stimulate the mammary tissue and enhance the risk of gynecomastia in sensitive individuals.

Combating the estrogenic side effects of Nandrolone can be achieved by the use of anti-estrogen medications, specifically Aromatase Inhibitors (AI’s) such as Anastrozole ( Arimidex ). Selective Estrogen Receptor Modulators (SERM’s) are also sometimes used, such as Tamoxifen ( Nolvadex ). However, AI’s are the proper choice as they will directly reduce serum estrogen levels and SERM’s will not. An AI should be enough to reduce and avoid gynecomastia unless the individual already has existing gynecomastia that could potentially be exasperated.

Important Note: It’s often been said that Nandrolone based gynecomastia is based on increases in prolactin. It is true that 19-nor steroids can increase prolactin, which can also negatively affect libido and erection function. Some men may need to use a dopamine agonist to combat this. However, it is not prolactin that causes 19-nor based gynecomastia but rather the imbalance between estrogen and progesterone. If you merely combat prolactin you may find yourself with the very gynecomastia you tried to avoid.
 

Nandrolone decanoate in the form of the Organon product, Deca-Durabolin, has been around for over 30 years. It has anabolic, androgenic, progestogenic and erythropoietic activity. The steroid maintains the anabolic activity of testosterone but the androgenic action is markedly diminished. The anabolic/androgenic quotient after 2 weeks of treatment has been shown to be 12 times that obtained with testosterone decanoate. Nandrolone decanoate has been shown to influence calcium metabolism positively and to increase bone mass in osteoporosis. Androgenic effects are relatively uncommon at the recommended therapeutic dosages.

SIDE EFFECTS:
It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.

Nandrolone what is it used for

nandrolone what is it used for

Nandrolone decanoate in the form of the Organon product, Deca-Durabolin, has been around for over 30 years. It has anabolic, androgenic, progestogenic and erythropoietic activity. The steroid maintains the anabolic activity of testosterone but the androgenic action is markedly diminished. The anabolic/androgenic quotient after 2 weeks of treatment has been shown to be 12 times that obtained with testosterone decanoate. Nandrolone decanoate has been shown to influence calcium metabolism positively and to increase bone mass in osteoporosis. Androgenic effects are relatively uncommon at the recommended therapeutic dosages.

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